September 2023. Volume 19. Number 3

Expectant management or early ibuprofen for patent ductus arteriosus in extremely premature infants?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, De Vries WB, Dijkman KP, et al. BeNeDuctus Trial Investigators. Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus. N Engl J Med. 2023; 388:980-90.

Reviewers: Carvajal Encina F1, Aizpurua Galdeano P2.
1UPC Neonatal. Hospital La Serena. Facultad de Medicina. Universidad Católica del Norte. Coquimbo. La Serena. Elqui. Chile.
2Pediatra. CS Ondarreta. San Sebastián. Guipúzcoa. España.
Correspondence: Fernando Carvajal Encina. Email: fcarvajal@ucn.cl
Reception date: 07/08/2023
Acceptance date: 18/08/2023
Publication date: 13/09/2023

Abstract

Authors´ conclusions: expectant management for Patent Ductus Arteriosus in extremely premature infants was noninferior to early ibuprofen treatment with respect to necrotizing enterocolitis, bronchopulmonary dysplasia, or death at 36 weeks' postmenstrual age.

Reviewers' comment: although the study has low statistical power that limits its precision, its results reinforce previous evidence that does not support early treatment of patent ductus arteriosus with ibuprofen in extremely preterm infants. Expectant management shows similar results to ibuprofen at 36 weeks postmenstrual age without exposing newborns to possible drug side effects.

How to cite this article

Carvajal Encina F, Aizpurúa Galdeano P. ¿Manejo expectante o ibuprofeno precoz en el ductus arterioso persistente en prematuros extremos? Evid Pediatr. 2023;19:27.

AVC | Critically appraised articles

Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, De Vries WB, Dijkman KP, et al. BeNeDuctus Trial Investigators. Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus. N Engl J Med. 2023; 388:980-90.

Reviewers: Carvajal Encina F1, Aizpurua Galdeano P2.
1UPC Neonatal. Hospital La Serena. Facultad de Medicina. Universidad Católica del Norte. Coquimbo. La Serena. Elqui. Chile.
2Pediatra. CS Ondarreta. San Sebastián. Guipúzcoa. España.
Correspondence: Fernando Carvajal Encina. Email: fcarvajal@ucn.cl
Reception date: 07/08/2023
Acceptance date: 18/08/2023
Publication date: 13/09/2023

How to cite this article

Carvajal Encina F, Aizpurúa Galdeano P. ¿Manejo expectante o ibuprofeno precoz en el ductus arterioso persistente en prematuros extremos? Evid Pediatr. 2023;19:27.

13/09/2023

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