September 2011. Volume 7. Number 3

Celiac disease could be detected with a determination of anti-transglutaminase antibodies in saliva

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Bonamico M, Nenna R, Montuori M, Luparia RP, Turchetti A, Mennini M et al. First salivary screening of celiac disease by detection of anti-transglutaminase autoantibody radioimmunoassay in 5000 Italian primary schoolchildren. J Pediatr Gastroenterol Nutr. 2011;52:17-20
Reviewers: Cuestas Montañés E1, Ortega Páez E2.
1Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Eduardo José Cuestas Montañés. Email: eduardo.cuestas@gmail.com
Reception date: 09/04/2011
Acceptance date: 10/04/2011
Publication date: 08/06/2011

Abstract

Authors' conclusions: we demostrated that is possible to perform a powerful, simple, well accepted and sensitive celiac disease (CD) screening using saliva.

Reviewers' commentary: this study describes the possibility to perform a simple, safe and apparently specific screening test for detecting CD in saliva at early age. This could contribute to reduce morbidity and mortality associated with CD. Further studies will be neccessary to confirm these results.

How to cite this article

Cuestas Montañés E, Ortega Páez E. La enfermedad celíaca se podría detectar con una determinación de anticuerpos antitransglutaminasa en la saliva. Evid Pediatr. 2011;7:56.

AVC | Critically appraised articles

Bonamico M, Nenna R, Montuori M, Luparia RP, Turchetti A, Mennini M et al. First salivary screening of celiac disease by detection of anti-transglutaminase autoantibody radioimmunoassay in 5000 Italian primary schoolchildren. J Pediatr Gastroenterol Nutr. 2011;52:17-20
Reviewers: Cuestas Montañés E1, Ortega Páez E2.
1Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
2CS Maracena. Distrito metropolitano. Granada. España.
Correspondence: Eduardo José Cuestas Montañés. Email: eduardo.cuestas@gmail.com
Reception date: 09/04/2011
Acceptance date: 10/04/2011
Publication date: 08/06/2011

How to cite this article

Cuestas Montañés E, Ortega Páez E. La enfermedad celíaca se podría detectar con una determinación de anticuerpos antitransglutaminasa en la saliva. Evid Pediatr. 2011;7:56.

References

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  2. Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther. 2007;26:1217-25.
  3. Bonamico M, Ferri M, Nenna R, Verrienti A, Di Mario U, Tiberti C. Tissue transglutaminase autoantibody detection in human saliva: a powerful method for celiac disease screening. J Pediatr. 2004;9:69-76.
  4. Walker-Smith JA, Guandalini S, Schmitz J, Shmerling DH, Visakorpi JK. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child. 1990;65:909-11.
  5. Akobeng AK, Thomas AG. Systematic review: tolerable amount of gluten for people with coeliac disease. Aliment Pharmacol Ther. 2008;27:1044-52.


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