September 2011. Volume 7. Number 3

Rotavirus vaccines and intussusception: Can we remain at ease?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Buttery JP, Danchin MH, Lee KJ, Carlin JB, McIntyre PB, Elliott EJ. Intussusception following rotavirus vaccine administration: post-marketing surveillance in the National Immunization Program in Australia. Vaccine. 2011;29:3061-6.
Reviewers: Ortega Páez E1, Cuestas Montañés E2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Eduardo Ortega Páez. Email: eortega.paez@gmail.com
Reception date: 22/07/2011
Acceptance date: 23/07/2011
Publication date: 17/08/2011

Abstract

Authors' conclusion: although this study did not find an increased risk of intussusception after administration of vaccines against rotavirus, there was some evidence of increased risk after the first dose of both vaccines. Larger population studies are needed to provide more definite evidence.

Reviewers' commentary: At the moment there is insufficient evidence to suggest that rotavirus vaccines are unsafe, but close monitoring should continue to determine if there is a possible association with intussusception.

How to cite this article

Ortega Páez E, Cuesta Montañés E. Vacunas antirotavirus e invaginación intestinal: ¿podemos seguir tranquilos? Evid Pediatr. 2011;7:70.

AVC | Critically appraised articles

Buttery JP, Danchin MH, Lee KJ, Carlin JB, McIntyre PB, Elliott EJ. Intussusception following rotavirus vaccine administration: post-marketing surveillance in the National Immunization Program in Australia. Vaccine. 2011;29:3061-6.
Reviewers: Ortega Páez E1, Cuestas Montañés E2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Eduardo Ortega Páez. Email: eortega.paez@gmail.com
Reception date: 22/07/2011
Acceptance date: 23/07/2011
Publication date: 17/08/2011

How to cite this article

Ortega Páez E, Cuesta Montañés E. Vacunas antirotavirus e invaginación intestinal: ¿podemos seguir tranquilos? Evid Pediatr. 2011;7:70.

References

  1. Parashar UD, Gibson CJ, Bresse JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerg Infect Dis. 2006;12:304-6.
  2. Ruiz-Palacios GM, Pérez-Schael I, Velázquez FR, Abate H, Breuer T, Clemens SC et al. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med. 2006;354:11-22.
  3. Vesikari T, Matson DO, Dennehy P, Van Damme P, Santosham M, Rodriguez Z et al. Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med. 2006;354:23-33.
  4. Safety of rotavirus vaccines: postmarketing surveillance in the WHO Region of the Americas. Wkly Epidemiol Rec. 2011;86:66-72.
  5. Food and Drug Administration (FDA). Information on RotaTeq and Intussusception.FDA Public Health Notification. February 13, 2007 [en línea] [fecha de consulta: 30-VII-2011]. Disponible en: http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm142404.htm
  6. Ruiz-Aragón J, Márquez-Peláez S, Villegas R. Eficacia y seguridad de las vacunas antirrotavirus. Revisión sistemática de la literatura científica. Vacunas. 2007;8:182-90.
17/08/2011

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