December 2011. Volume 7. Number 4

Is sequential therapy for Helicobacter pylori replacing triple therapy?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Albrecht P, Kotowska M, Szajewska H. Sequential Therapy Compared with Standard Triple Therapy for Helicobacter Pylori eradication in children: a double-blind, randomized, controlled trial. J Pediatr. 2011;159:45-9.
Reviewers: Ortega Páez E1, Cuestas Montañés E2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Eduardo Ortega Páez. Email: eortega.paez@gmail.com
Reception date: 20/10/2011
Acceptance date: 21/10/2011
Publication date: 16/11/2011

Abstract

Authors' conclusion: in children with Helicobacter pylori infection sequential eradication therapy compared with standard triple therapy resulted in a higher eradication rate, although the difference was of borderline statistical significance.

Reviewers' commentary: sequential therapy versus triple therapy for the treatment of Helicobacter pylori infection in childhood shows a slight superiority in the limit of statistical significance. Although some treatment guidelines recommend sequential therapy as the first choice, further studies of quality are needed to consider it as such. Meanwhile, the sequential therapy could be considered a valid alternative to the triple one.

How to cite this article

Ortega Páez E, Cuestas E. ¿Está desplazando la terapia secuencial a la triple terapia en la infección por Helicobacter pylori? Evid Pediatr. 2011;7:95.

AVC | Critically appraised articles

Albrecht P, Kotowska M, Szajewska H. Sequential Therapy Compared with Standard Triple Therapy for Helicobacter Pylori eradication in children: a double-blind, randomized, controlled trial. J Pediatr. 2011;159:45-9.
Reviewers: Ortega Páez E1, Cuestas Montañés E2.
1CS Maracena. Distrito metropolitano. Granada. España.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Eduardo Ortega Páez. Email: eortega.paez@gmail.com
Reception date: 20/10/2011
Acceptance date: 21/10/2011
Publication date: 16/11/2011

How to cite this article

Ortega Páez E, Cuestas E. ¿Está desplazando la terapia secuencial a la triple terapia en la infección por Helicobacter pylori? Evid Pediatr. 2011;7:95.

References

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  2. Koletzko S, Richy F, Bontems P, Crone J, Kalach N, Monteiro ML et al. Prospectivemulticentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut. 2006;55:1711-6.
  3. Francavilla R, Lionetti E, Castellaneta SP, Magistà AM, Boscarelli G, Piscitelli D et al. Improved efficacy of 10-Day sequential treatment for Helicobacter pylori eradication in children: a randomized trial. Gastroenterology. 2005;129:1414-9.
  4. Tong JL, Ran ZH, Shen J, Xiao SD. Sequential therapy vs standard triple therapies for Helicobacter pylori infection: a meta-analysis. J Clin Pharm Ther. 2009;34:41-53.
  5. Molina Arias M, Martínez-Ojinaga Nodal E. Helicobacter pylori. Tras la tempestad, ¿vendrá la calma? Evid Pediatr. 2010;6:26.
  6. Koletzko S, Jones NL, Goodman KJ, Gold B, Rowland M, Cadranel S et al. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr. 2011;53:230-43.
16/11/2011

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