June 2015. Volume 11. Number 2

Se observan avances en el desarrollo de una vacuna contra el dengue

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Villar L, Dayan GH, Arredondo-García JL, Rivera DM, Cunha R, Deseda C, et al. Efficacy of a tetravalent dengue vaccine in children in Latin America. N Engl J Med. 2015;372:113-23.
Reviewers: Carvajal Encina F1, Cuestas Montañés E2.
1UCIN Hospital de La Serena y Escuela de Medicina Universidad Católica del Norte. La Serena. Elqui. Chile.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Fernando Carvajal Encina. Email: fcarvajal@ucn.cl
Reception date: 30/04/2015
Acceptance date: 31/05/2015
Publication date: 20/05/2015

Abstract

Author’s conclusions: the CYD-TDV dengue vaccine was efficacious against VCD and severe VCD and led to fewer hospitalizations for VCD in five Latin American countries where dengue is endemic.

Reviewers’ commentary: data on immunologic correlates are still modest but appears to have a significant impact on severity and mortality. Long-term follow-up of vaccines will be essential to understand whether waning vaccine-elicited immunity predisposes recipients to more severe outcomes on subsequent natural infection. For now, pediatricians should remains optimistic that one day will be possible to prevent dengue.

Key words: dengue; vaccine

How to cite this article

Carvajal Encina F, Cuestas E. Se observan avances en el desarrollo de una vacuna contra el Dengue. Evid Pediatr. 2015;11:31.

AVC | Critically appraised articles

Villar L, Dayan GH, Arredondo-García JL, Rivera DM, Cunha R, Deseda C, et al. Efficacy of a tetravalent dengue vaccine in children in Latin America. N Engl J Med. 2015;372:113-23.
Reviewers: Carvajal Encina F1, Cuestas Montañés E2.
1UCIN Hospital de La Serena y Escuela de Medicina Universidad Católica del Norte. La Serena. Elqui. Chile.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Fernando Carvajal Encina. Email: fcarvajal@ucn.cl
Key words: dengue; vaccine
Reception date: 30/04/2015
Acceptance date: 31/05/2015
Publication date: 20/05/2015

How to cite this article

Carvajal Encina F, Cuestas E. Se observan avances en el desarrollo de una vacuna contra el Dengue. Evid Pediatr. 2015;11:31.

References

  1. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496:504-7.
  2. Stahl HC, Butenschoen VM, Tran HT, Gozzer E, Skewes R, Mahendradhata Y, et al. Cost of dengue outbreaks: literature review and country case studies. BMC Public Health. 2013;13:1048.
  3. Rothman AL. Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nat Rev Immunol. 2011;11:532-43.
  4. Thomas SJ, Endy TP. Critical issues in dengue vaccine development. Curr Opin Infect Dis. 2011;5:442-50.
20/05/2015

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