September 2015. Volume 11. Number 3

La utilización de soluciones isotónicas para la hidratación parenteral de mantenimiento en niños hospitalizados evita la hiponatremia

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

McNab S, Duke T, South M, Babl FE, Lee KJ, Arnup SJ, et al. 140 mmol/l of sodium versus 77 mmol/l of sodium in maintenance intravenous fluid therapy for children in hospital (PIMS): a randomized controlled double-blind trial. Lancet. 2015;385:1190-7.
Reviewers: Modesto i Alapont V1, Cuestas Montañés E2.
1Unidad de Cuidados Intensivos Pediátricos. Hospital Infantil La Fe. Valencia. España.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Vicent Modesto i Alapont. Email: vicent.modesto@gmail.com
Reception date: 02/06/2015
Acceptance date: 25/06/2015
Publication date: 01/07/2015

Abstract

Author’s conclusions: use of isotonic intravenous fluid with a sodium concentration of 140 mmol/l had a lower risk of hiponatremia, without an increase in adverse effects, than did fluid containing 77 mmol/l of sodium. An isotonic fluid should be used as intravenous fluid for maintenance hydration in children.

Reviewers’ commentary: isotonic solutions are safer than hypotonic solutions in hospitalized children requiring IV fluids therapy in terms of avoiding hiponatremia.

How to cite this article

Modesto i Alapont V, Cuestas E. La utilización de soluciones isotónicas para la hidratación parenteral de mantenimiento en niños hospitalizados evita la hiponatremia. Evid Pediatr. 2015;11:40.

AVC | Critically appraised articles

McNab S, Duke T, South M, Babl FE, Lee KJ, Arnup SJ, et al. 140 mmol/l of sodium versus 77 mmol/l of sodium in maintenance intravenous fluid therapy for children in hospital (PIMS): a randomized controlled double-blind trial. Lancet. 2015;385:1190-7.
Reviewers: Modesto i Alapont V1, Cuestas Montañés E2.
1Unidad de Cuidados Intensivos Pediátricos. Hospital Infantil La Fe. Valencia. España.
2Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
Correspondence: Vicent Modesto i Alapont. Email: vicent.modesto@gmail.com
Reception date: 02/06/2015
Acceptance date: 25/06/2015
Publication date: 01/07/2015

How to cite this article

Modesto i Alapont V, Cuestas E. La utilización de soluciones isotónicas para la hidratación parenteral de mantenimiento en niños hospitalizados evita la hiponatremia. Evid Pediatr. 2015;11:40.

References

  1. McNab S, Duke T, South M, Babl FE, Lee KJ, Arnup SJ, et al. 140 mmol/l of sodium versus 77 mmol/l of sodium in maintenance intravenous fluid therapy for children in hospital (PIMS): a randomized controlled double-blind trial. Lancet. 2015;385:1190-7.
  2. Holliday MA, Segar WE. The maintenance need for water in parenteral fluid therapy. Pediatrics. 1957;19:823-32.
  3. Arieff AI, Ayus JC, Fraser CL. Hyponatraemia and death or permanent brain damage in healthy children. BMJ. 1992;304:1218-22.
  4. McNab S, Ware RS, Neville KA, Choong K, Coulthard MG, Duke T, et al. Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children. Cochrane Database Syst Rev. 2014;12:CD009457.
  5. Padua AP, Macaraya JR, Dans LF, Anacleto FE Jr. Isotonic versus hypotonic saline solution for maintenance intravenous fluid therapy in children: a systematic review. Pediatr Nephrol. 2015;30:1163-72.
  6. Bitew S, Imbriano L, Miyawaki N, Fishbane S, Maesaka JK. More on renal salt wasting without cerebral disease: response to saline infusion. Clin J Am Soc Nephrol. 2009;4:309-15.
  7. Montañana PA, Modesto i Alapont V, Ocón AP, López PO, López Prats JL, Toledo Parreño JD. The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study. Pediatr Crit Care Med. 2008;9:589-97.

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