March 2020. Volume 16. Number 1

How long should we wait for blood culture results to rule out neonatal sepsis?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Durrani N, Rochow N, Alghamdi J, Pelc A, Fusch C, Dutta S. Minimum duration of antibiotic treatment based on blood culture in rule out neonatal sepsis. Pediatr Infect Dis J. 2019;38:528-32.

Reviewers: Aparicio Sánchez JL1, Cuestas Montañés E2.
1Servicio de Pediatría. Hospital Dr. José Molina Orosa. Lanzarote. Las Palmas. España.
2Servicio de Pediatría y Neonatología. Hospital Privado Universitario de Córdoba. Córdoba. Argentina.
Correspondence: José Luis Aparicio Sánchez. Email: japaricio1970@gmail.com
Reception date: 08/01/2020
Acceptance date: 14/01/2020
Publication date: 29/01/2020

Abstract

Authors’ conclusions: the probability of positive blood culture beyond 24 hours for a Gram-negative organism is small. Empiric antimicrobial treatment can be reduced after 24 hours to target only Gram-positive organisms in late onset sepsis and can be stopped in early onset sepsis unless clinical or laboratory parameters strongly suggest sepsis.

Reviewers’ commentary: depending on the local epidemiology, neonatologists could consider restrictively reviewing their antibiotic policies in the screening of neonatal sepsis, thus avoiding the overmedication of their neonates. It would seem reasonable to suspend treatment at 48 hours in patients with normal clinical and laboratory parameters.

How to cite this article

Aparicio Sánchez JL, Cuestas Montañés E. En la sepsis neonatal, el tiempo de crecimiento del hemocultivo puede ser definitivo. Evid Pediatr. 2020;16:2.

AVC | Critically appraised articles

Durrani N, Rochow N, Alghamdi J, Pelc A, Fusch C, Dutta S. Minimum duration of antibiotic treatment based on blood culture in rule out neonatal sepsis. Pediatr Infect Dis J. 2019;38:528-32.

Reviewers: Aparicio Sánchez JL1, Cuestas Montañés E2.
1Servicio de Pediatría. Hospital Dr. José Molina Orosa. Lanzarote. Las Palmas. España.
2Servicio de Pediatría y Neonatología. Hospital Privado Universitario de Córdoba. Córdoba. Argentina.
Correspondence: José Luis Aparicio Sánchez. Email: japaricio1970@gmail.com
Reception date: 08/01/2020
Acceptance date: 14/01/2020
Publication date: 29/01/2020

How to cite this article

Aparicio Sánchez JL, Cuestas Montañés E. En la sepsis neonatal, el tiempo de crecimiento del hemocultivo puede ser definitivo. Evid Pediatr. 2020;16:2.

29/01/2020

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