Authors’ conclusions: prophylactic antipyretics affect immune responses to vaccines; these effects vary depending on the vaccine, antipyretic agent, and time of administration. In infants, paracetamol may interfere with immune responses to pneumococcal antigens, and ibuprofen may reduce responses to pertussis and tetanus antigens. The use of antipyretics for fever prophylaxis during infant vaccination merits careful consideration.
Reviewers’ commentary: this study suggests that the best immune response to vaccination is reached without the use of prophylactic antipyretics.
Juanes de Toledo B, González Rodríguez MP. Evid Pediatr. 2017;13:34
Authors’ conclusions: despite the resilience demonstrated by some of the adopted children and the remission of problems in the adult age in some cases, prolonged early deprivation was associated with adverse effects on the long term on the wellness of the studied children and this situation was not susceptible to improvement even after years of adequate care and support by adopting families.
Reviewers’ commentary: this is a well-designed study with a control group that evaluates the impact of prolonged deprivation in infancy on posterior development. The conclusions indicate that the long-term problems can become permanent despite the inclusion in a normal familial environment.
Perdikidis Olivieri L, Esparza Olcina MJ. Evid Pediatr. 2017;13:35
Authors’ conclusions: mobile health interventions appear to be a viable health behavior change intervention modality for youth. Given the ubiquity of mobile phones, mobile health interventions offer promise in improving public health.
Reviewers’ commentary: despite its low validity, this meta-analysis shows a favorable effect of interventions to improve health, through mobile telephony, in children and adolescents.
Rodríguez-Salinas Pérez E, Aizpurua Galdeano P. Evid Pediatr. 2017;13:36
Authors’ conclusions: adalimumab, added to the usual therapy with methotrexate, achieves significantly better control of juvenile idiopathic arthritis associated with uveitis in children and adolescents, although the rate of side effects is much higher with this drug.
Reviewers’ commentary: with the available data, associating adalimumab to methotrexate seems effective for the treatment of uveitis associated with juvenile idiopathic arthritis in children and adolescents, but the described adverse events and costs should be taken into account and should be used with caution.
Ruiz-Canela Cáceres J, García Vera C. Evid Pediatr. 2017;13:37
Authors’ conclusions: the use of a combined strategy in multiple phases in the management of premature child reduced the incidence of late sepsis to 88% with respect to the pre-intervention values and also the incidence of infections of the central venous catheters.
Reviewers’ commentary: this is a well designed and executed study although due to the fact that it was not randomized and the controls were of historical type, we cannot assume the direct applicability of the results.
Authors´ conclusions: among comatose children who survived in-hospital cardiac arrest, therapeutic hypothermia, as compared with therapeutic normothermia, did not confer a significant benefit in survival with a favorable functional outcome at 1 year.
Reviewers´ commentary: in the controversy over the alleged benefits of therapeutic hypothermia, the results of this study found no differences to support its use against normothermia to improve survival with a favorable functional outcome after in-hospital cardiac arrest in children.
Martín-Crespo Blanco C, Aizpurua Galdeano P. Evid Pediatr. 2017;13:39
Authors’ conclusions: the use of computerized clinical decision support system to automate the identification and screening of pediatric patients, at high risk for type 2 diabetes mellitus, can help overcome barriers to the screening process by increasing screening among patients at risk and adherence to follow-up appointments.
Reviewers’ commentary: the use of the computerized support system described does not seem to provide substantial advantages for the screening and follow-up of older children and adolescents at risk of type 2 diabetes mellitus, although it does improve the adequacy to the criteria of good clinical practice.
Pérez-Moneo Agapito B, Rodríguez-Salinas Pérez E. Evid Pediatr. 2017;13:41
Authors’ conclusions: there is a short-term association between traffic-related air pollutants and fluctuations in attention, which could have deleterious effects on neurodevelopment.
Reviewers’ commentary: the results found in this study seem applicable to our environment, due to the characteristics of the population and the type of pollution studied. Although we cannot yet quantify the medium- and long-term impact of urban pollution, it seems to be some risk, which must be taken into account, because it is preventable, when establishing recommendations and restrictions in our cities.
Ochoa Sangrador C, Andrés de Llano JM. Evid Pediatr. 2017;13:42