December 2010. Volume 6. Number 4

Measles-Mumps-Rubella-Varicella combination vaccine could double the risk of febrile seizures compared to separate Measles-Mumps-Rubella and Varicella vaccines

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Klein NP, Fireman B, Yih WK, Lewis E, Kulldorff M, Ray P, et al. Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. Pediatrics. 2010;126:e1-8.
Reviewers: García Vera C1, Aizpurua Galdeano P2.
1CS Sagasta-Ruiseñores. Zaragoza. España.
2ABS 7 La Salut Badalona. Badalona. España.
Correspondence: César García Vera. Email: cgarciavera@gmail.com
Reception date: 13/10/2010
Acceptance date: 24/09/2010
Publication date: 21/10/2010

Abstract

Authors’ conclusions: among 12-23-month-olds receiving their first dose of Measles-Mumps-Rubella (MMR)  vaccine, the risk of fever and febrile seizures are elevated 7 to 10 days after vaccination. This already known risk increases with the Measles-Mumps-Rubella-Varicella (MMRV) vaccine, resulting in 1 additional febrile seizure for every 2,300 doses of this vaccine.

Reviewers’ commentary: this study, involving nearly half a million children, provides results that confirm prelicensure safety data about the increasing risk of febrile seizures 7 to 10 days after vaccination with the new MMRV vaccine, compared to separate MMR and Varicella vaccines. This risk is estimated to be 1 per 2,300 doses of the new vaccine. Paediatricians should be aware of this risk when recommending or not recommending this vaccine.

How to cite this article

García Vera C, Aizpurua Galdeano P. La vacuna cuádruple vírica (sarampión-rubéola-parotiditis-varicela) podría duplicar la incidencia de convulsiones febriles en comparación con la administración separada de las vacunas triple vírica y varicela. Evid Pediatr. 2010;6:82.

AVC | Critically appraised articles

Klein NP, Fireman B, Yih WK, Lewis E, Kulldorff M, Ray P, et al. Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures. Pediatrics. 2010;126:e1-8.
Reviewers: García Vera C1, Aizpurua Galdeano P2.
1CS Sagasta-Ruiseñores. Zaragoza. España.
2ABS 7 La Salut Badalona. Badalona. España.
Correspondence: César García Vera. Email: cgarciavera@gmail.com
Reception date: 13/10/2010
Acceptance date: 24/09/2010
Publication date: 21/10/2010

How to cite this article

García Vera C, Aizpurua Galdeano P. La vacuna cuádruple vírica (sarampión-rubéola-parotiditis-varicela) podría duplicar la incidencia de convulsiones febriles en comparación con la administración separada de las vacunas triple vírica y varicela. Evid Pediatr. 2010;6:82.

References

  1. Chen RT, Glasser JW, Rhodes PH, Davis RL, Barlow WE, Thompson RS, et al. Vaccine Safety Datalink project: a new tool for improving vaccine safety monitoring in the United States. Pediatrics. 1997;99:765-73
  2. Ochoa Sangrador C, Orejón de Luna G. La vacuna combinada frente a sarampión, parotiditis, rubéola y varicela presenta una inmunogenicidad similar a las vacunas triple vírica y varicela administradas por separado, a expensas de un gran aumento de la carga de virus varicela atenuado en la vacuna tetravalente. Evid Pediatr. 2006;2:3
  3. European Medicines Agency. Document Library. Ficha técnica Proquad [en línea] [consultado 3 de octubre de 2010]. Disponible en: http://www.ema.europa.eu/docs/es_ES/document_library/EPAR-_Product_Information/human/000622/WC500044070.pdf
  4. Centers for Disease Control and Prevention; Advisory Committee on Immunization Practices. Update: recommendations from the Advisory Committee on Immunization Practices (ACIP) regarding administration of combination MMRV vaccine. MMWR Morb Mortal Wkly Rep. 2008;57:258-60

21/10/2010

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