December 2015. Volume 11. Number 4

In routine immunization of extremely premature infants: do the risks outweigh the benefits?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

DeMeo SD, Raman SR, Hornik CP, Wilson CC, Clark R, Smith PB. Adverse events after routine immunization of extremely low-birth-weight-infants. JAMA Pediatr. 2015:169:740.
Reviewers: Aparicio Rodrigo M1, Martínez Rubio M.V2.
1Centro de Salud Entreví­as. Área 1. Madrid. España.
2CS Los Fresnos. Torrejón de Ardoz. Madrid. España.
Correspondence: María Aparicio Rodrigo. Email: maparicio@salud.madrid.org
Reception date: 30/10/2015
Acceptance date: 14/11/2015
Publication date: 16/12/2015

Abstract

Authors' conclusions: all extremely low birth weight infants in the neonatal intensive care units have an increased incidence of sepsis evaluations and of increased respiratory support and intubation after routine immunization. These findings don't suggest that physicians should not use vaccines in extremely low birth weight infants.

Reviewers' commentary: vaccination of extremely low birth weight infants in the neonatal intensive care units can increase studies to rule out sepsis, with no real increase in this disease, respiratory support and intubation without a clear clinical meaning. These results do not contraindicate vaccination in these patients, as the benefits outweigh the risks. The use of combined vaccines does not increase the incidence of adverse effects.

How to cite this article

Aparicio Rodrigo M, Martínez Ruibo V. En la vacunación de los prematuros extremos, ¿los riesgos superan a los beneficios? Evid Pediatr. 2015;11:64.

AVC | Critically appraised articles

DeMeo SD, Raman SR, Hornik CP, Wilson CC, Clark R, Smith PB. Adverse events after routine immunization of extremely low-birth-weight-infants. JAMA Pediatr. 2015:169:740.
Reviewers: Aparicio Rodrigo M1, Martínez Rubio M.V2.
1Centro de Salud Entreví­as. Área 1. Madrid. España.
2CS Los Fresnos. Torrejón de Ardoz. Madrid. España.
Correspondence: María Aparicio Rodrigo. Email: maparicio@salud.madrid.org
Reception date: 30/10/2015
Acceptance date: 14/11/2015
Publication date: 16/12/2015

How to cite this article

Aparicio Rodrigo M, Martínez Ruibo V. En la vacunación de los prematuros extremos, ¿los riesgos superan a los beneficios? Evid Pediatr. 2015;11:64.

References

  1. Manual de vacunas AEP. Vacunación de niños prematuros. En: Comité Asesor de Vacunas de la AEP [en línea] [consultado el 13/11/2015]. Disponible en: http://vacunasaep.org/documentos/manual/cap-10
  2. Denizot S, Fleury J, Caillaux G, Rouger V, Rozé JC, Gras-Le Guen C. Hospital initiation of a vaccinal schedule improves the long-term vaccinal coverage of ex-preterm children. Vaccine. 2011;29:382-6.
  3. Navar Boggan AM, Halsy NA, Golden WC, Escobar GJ,Massolo M, Klein NP. Risk of fever and sepsis evaluations after routine immunizations in the neonatal intensive care unit. J Perinatol. 2010;30:604-9.
  4. Hacking DF, Davis PG, Wong E, Wheeler K, McVernon J. Frequency of respiratory deterioration after immunisation in preterm infants. J Paediatr Child Health. 2010;46:742-8.
  5. Furck AK, Richter JW, Kattner E. Very low birth weight infants have only few adverse events after timely immunization. J Perinatol. 2010;30:118-21.

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