December 2025. Volume 21. Number 4

Controlled provocation tests are still necessary to safely rule out beta-lactam allergy

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Wilkins AL, Pittet LF, Kyriakou S, Walker K, Donath S, Choo S, et al. Allergy to beta-lactam antibiotics in children: predictors for a positive oral challenge test. Arch Dis Child. 2024:13;110(1):31-7.

Reviewers: Oltra Benavent M1, Suárez Cabezas S2.
1Sección de Patología Infecciosa Infantil. Hospital Universitari i Politècnic La Fe. Valencia. España.
2Servicio de Pediatría. Hospital Virgen de Altagracia. Manzanares. Ciudad Real. España.
Correspondence: Manuel Oltra Benavent . Email: oltra.benavent@gmail.com
Reception date: 04/12/2025
Acceptance date: 15/12/2025
Publication date: 23/12/2025

Abstract

Authors´ conclusions: positive results in controlled challenge tests for suspected beta-lactam allergy are infrequent and are associated with a history of other drug allergies and index reactions that were severe, immediate, and/or required adrenaline.

Reviewers´ commentary: controlled challenge tests remain necessary to safely rule out beta-lactam allergy, as there is no robust evidence of the usefulness of valid predictive risk factors to define low-risk populations for positive tests.

How to cite this article

Oltra Benavent M, Suárez Cabezas S. Las pruebas de provocación controladas siguen siendo necesarias para descartar con seguridad la alergia a los betalactámicos. Evid Pediatr. 2025;21:49.

AVC | Critically appraised articles

Wilkins AL, Pittet LF, Kyriakou S, Walker K, Donath S, Choo S, et al. Allergy to beta-lactam antibiotics in children: predictors for a positive oral challenge test. Arch Dis Child. 2024:13;110(1):31-7.

Reviewers: Oltra Benavent M1, Suárez Cabezas S2.
1Sección de Patología Infecciosa Infantil. Hospital Universitari i Politècnic La Fe. Valencia. España.
2Servicio de Pediatría. Hospital Virgen de Altagracia. Manzanares. Ciudad Real. España.
Correspondence: Manuel Oltra Benavent . Email: oltra.benavent@gmail.com
Reception date: 04/12/2025
Acceptance date: 15/12/2025
Publication date: 23/12/2025

How to cite this article

Oltra Benavent M, Suárez Cabezas S. Las pruebas de provocación controladas siguen siendo necesarias para descartar con seguridad la alergia a los betalactámicos. Evid Pediatr. 2025;21:49.

23/12/2025

Linked Comment

Methodological note