September 2009. Volume 5. Number 3

An 11-valent pneumococcal conjugate vaccine does not prevent significantly the community-acquired radiologically confirmed pneumonia in children younger than 2 years of age

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Lucero MG, Nohynek H, Williams G, Tallo V, Simões EA, Lupisan S, et al. Efficacy of an 11-valent pneumococcal conjugate vaccine against radiologically confirmed pneumonia among children less than 2 years of age in the Philippines: a randomized, double-blind, placebo-controlled trial. Pediatr Infect Dis J. 2009;28:455-62
Reviewers: Ochoa Sangrador C1, Andrés de Llano JM2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Servicio de Pediatría. Hospital General del Río Carrión. Palencia. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas@meditex.es
Reception date: 03/08/2009
Acceptance date: 11/08/2009
Publication date: 10/09/2009

Abstract

Authors' conclusions: an 11-valent pneumococcal conjugate vaccine produces a 22.9% reduction of community-acquired radiologically confirmed pneumonia in children younger than 2 years of age; this fact suggests that at least one-fifth of these pneumonias are caused by pneumococcus.

Reviewers' commentary: an 11-valent pneumococcal conjugate vaccine does not prevent significantly the community-acquired radiologically confirmed pneumonia in children younger than 2 years of age. Although it is predictable, considering other studies, that this vaccine could prevent a percentage of pneumonias, its use will continue being based on the prevention of invasive pneumococcal disease, since it is risky to estimate the impact of the vaccine on other outcomes.

How to cite this article

Ochoa Sangrador C, Andrés de Llano J. Una vacuna neumocócica conjugada 11-valente no reduce significativamente las neumonías adquiridas en la comunidad con diagnóstico radiológico en niños menores de dos años. Evid Pediatr. 2009;5:63.

AVC | Critically appraised articles

Lucero MG, Nohynek H, Williams G, Tallo V, Simões EA, Lupisan S, et al. Efficacy of an 11-valent pneumococcal conjugate vaccine against radiologically confirmed pneumonia among children less than 2 years of age in the Philippines: a randomized, double-blind, placebo-controlled trial. Pediatr Infect Dis J. 2009;28:455-62
Reviewers: Ochoa Sangrador C1, Andrés de Llano JM2.
1Servicio de Pediatría. Hospital Virgen de la Concha. Zamora. España.
2Servicio de Pediatría. Hospital General del Río Carrión. Palencia. España.
Correspondence: Carlos Ochoa Sangrador. Email: cochoas@meditex.es
Reception date: 03/08/2009
Acceptance date: 11/08/2009
Publication date: 10/09/2009

How to cite this article

Ochoa Sangrador C, Andrés de Llano J. Una vacuna neumocócica conjugada 11-valente no reduce significativamente las neumonías adquiridas en la comunidad con diagnóstico radiológico en niños menores de dos años. Evid Pediatr. 2009;5:63.

References

  1. Lucero MG, Dulalia VE, Parreno RN, Lim-Quianzon DM, Nohynek H, Makela H, Williams G. Vacunas conjugadas antineumocócicas para la prevención de la neumonía con consolidación radiográfica y la enfermedad neumocócica invasiva por los serotipos de la vacuna en niños menores de dos años de edad (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2008 Número 2. Oxford: Update Software Ltd. Disponible en: http://www.update-software.com. (Traducida de The Cochrane Library, 2008 Issue 2. Chichester , UK : John Wiley & Sons, Ltd.).
  2. Black S, Shinefield H, Ling S, Hansen J, Fireman B, Spring D, et al. Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia. Pediatr Infect Dis J. 2002;21:810-5.
  3. Klugman KP, Madhi SA, Huebner RE, Kohberger R, Mbelle N, Pierce N, et al. A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engl J Med. 2003;349:1341-8.
  4. Cutts FT, Zaman SM, Enwere G, Jaffar S, Levine OS, Okoko JB, et al. Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial. Lancet. 2005;365:1139-46.
  5. Cuestas E., Buñuel Álvarez JC. La vacuna antineumocócica no previene la otitis media con derrame. Evid Pediatr. 2008;4:35.
  6. Orejón de Luna G, Ochoa Sangrador C. Una nueva vacuna frente a 11 serotipos de Streptococcus pneumoniae, conjugada con una proteína de Haemophilus influenzae, reduce escasamente las otitis, diagnosticadas de forma restringida, en los dos primeros años de vida. Evid Pediatr. 2006;2:28.
  7. Ruiz-Canela Cáceres J, Juanes de Toledo B. Enfermedad Neumocócica Invasiva: aumento de la incidencia de serotipos no vacunales tras la vacunación universal de los niños nativos de Alaska. Evid Pediatr. 2007;3:74.
10/09/2009

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