June 2014. Volume 10. Number 2

Packed red blood cell transfusion can increase the risk of developing necrotizing enterocolitis in premature infants

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Wan-Huen P, Bateman D, Shapiro DM, Parravicini E. Packed red blood cell transfusion is an independent risk factor for necrotizing enterocolitis in premature infants. J Perinatol. 2013;33:786-90.
Reviewers: Carvajal Encina F1, Ibáñez Pradas V2.
1UCIN Hospital de La Serena y Escuela de Medicina Universidad Católica del Norte. La Serena. Elqui. Chile.
2 Servicio de Cirugía Pediátrica. Hospital General de Castellón. Valencia. Valencia. España.
Correspondence: Fernando Carvajal Encina. Email: fcarvajal@ucn.cl
Reception date: 07/03/2014
Acceptance date: 12/03/2014
Publication date: 07/05/2014

Abstract

Authors’ conclusions: packed red cells transfusion in very low birth-weight newborns is an independent risk factor for necrotizing enterocolitis.

Reviewers’ commentary: this study joins the current literature warning about a link between red cell transfusion and necrotizing enterocolitis. In spite of its design, a case-control study, results are similar to previous studies with larger samples, increasing the likelihood of this connection. Neither this study nor previous ones clarify whether there is a causal relation between both events or if it is just a manifestation of other factors causing enterocolitis.

How to cite this article

Carvajal Encina F, Ibáñez Pradas V. La transfusión de concentrado de hematíes puede aumentar el riesgo de enterocolitis necrotizante en prematuros. Evid Pediatr. 2014;10:27.

AVC | Critically appraised articles

Wan-Huen P, Bateman D, Shapiro DM, Parravicini E. Packed red blood cell transfusion is an independent risk factor for necrotizing enterocolitis in premature infants. J Perinatol. 2013;33:786-90.
Reviewers: Carvajal Encina F1, Ibáñez Pradas V2.
1UCIN Hospital de La Serena y Escuela de Medicina Universidad Católica del Norte. La Serena. Elqui. Chile.
2 Servicio de Cirugía Pediátrica. Hospital General de Castellón. Valencia. Valencia. España.
Correspondence: Fernando Carvajal Encina. Email: fcarvajal@ucn.cl
Reception date: 07/03/2014
Acceptance date: 12/03/2014
Publication date: 07/05/2014

How to cite this article

Carvajal Encina F, Ibáñez Pradas V. La transfusión de concentrado de hematíes puede aumentar el riesgo de enterocolitis necrotizante en prematuros. Evid Pediatr. 2014;10:27.

References

  1. McGrady GA, Rettig PJ, Istre GR, Jason JM, Holman RC, Evatt BL. An outbreak of necrotizing enterocolitis. Association with transfusions of packed red blood cells. Am J Epidemiol. 1987;126:1165-72.
  2. Paul DA, Mackley A, Novitsky A, Zhao Y, Brooks A, Locke RG. Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants. Pediatrics. 2011;127:635-41.
  3. Josephson CD, Wesolowski A, Bao G, Sola-Visner MC, Dudell G, Castillejo MI, et al. Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants? J Pediatr. 2010;157:972-978.e1-3.
  4. Mally P, Golombek SG, Mishra R, Nigam S, Mohandas K, Depalhma H, et al. Association of necrotizing enterocolitis with elective packed red blood cell transfusions in stable, growing, premature neonates. Am J Perinatol. 2006;23:451-8.
  5. Mohamed A, Shah PS. Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data. Pediatrics. 2012;129:529-40.
  6. Keir AK, Wilkinson D. Question 1: Do feeding practices during transfusion influence the risk of developing necrotising enterocolitis in preterm infants? Arch Dis Child. 2013;98:386-8.
07/05/2014

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