September 2021. Volume 17. Number 3

Septic children's mortality triples when choosing inappropriate empiric antibiotics initially

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Cook A, Hsia Y, Russell N, Sharland M, Cheung K, Grimwood K, et al. Association of empiric antibiotic regimen discordance with 30-day mortality in neonatal and pediatric bloodstream infection-a global retrospective cohort study. Pediatr Infect Dis J. 2021;40:137-43.
Reviewers: Rodríguez-Salinas Pérez E1, Cuestas Montañés EJ2.
1Pediatra. CS Colmenar Viejo Norte. Colmenar Viejo. Madrid. España.
2Servicio de Pediatría y Neonatología. Hospital Privado Universitario de Córdoba. Córdoba. Argentina.
Correspondence: Enrique Rodríguez-Salinas Pérez. Email: kiksalinas@gmail.com
Reception date: 02/09/2021
Acceptance date: 15/09/2021
Publication date: 29/09/2021

Abstract

Authors’ conclusions: odds of mortality in confirmed pediatric BSI are nearly 3-fold higher for patients receiving a discordant early empiric antibiotic regimen. The impact of improved concordance of early empiric treatment on mortality, particularly in critically ill patients, needs further evaluation.

Reviewers’ commentary: this multicenter study confirms the importance of a correct choice of antibiotic regimen in the first 2 days, while the antibiogram arrives, for children with proven sepsis.

How to cite this article

Rodríguez-Salinas Pérez E, Cuestas Montañés E. La mortalidad de los niños sépticos se triplica al elegir inicialmente antibióticos empíricos inadecuados. Evid Pediatr. 2021;17:35.

AVC | Critically appraised articles

Cook A, Hsia Y, Russell N, Sharland M, Cheung K, Grimwood K, et al. Association of empiric antibiotic regimen discordance with 30-day mortality in neonatal and pediatric bloodstream infection-a global retrospective cohort study. Pediatr Infect Dis J. 2021;40:137-43.
Reviewers: Rodríguez-Salinas Pérez E1, Cuestas Montañés EJ2.
1Pediatra. CS Colmenar Viejo Norte. Colmenar Viejo. Madrid. España.
2Servicio de Pediatría y Neonatología. Hospital Privado Universitario de Córdoba. Córdoba. Argentina.
Correspondence: Enrique Rodríguez-Salinas Pérez. Email: kiksalinas@gmail.com
Reception date: 02/09/2021
Acceptance date: 15/09/2021
Publication date: 29/09/2021

How to cite this article

Rodríguez-Salinas Pérez E, Cuestas Montañés E. La mortalidad de los niños sépticos se triplica al elegir inicialmente antibióticos empíricos inadecuados. Evid Pediatr. 2021;17:35.

29/09/2021

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