June 2026. Volume 22. Number 2

Intranasal Midazolam for Pediatric Emergency Sedation: What is the Optimal Dose?

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Tsze DS, Woodward HA, McLaren SH, Leu CS, Venn AMR, Hu NY, et al. Optimal dose of intranasal midazolam for procedural sedation in children: a randomized clinical trial. JAMA Pediatr. 2025;179:979-86. 

Reviewers: Rivero Martín MJ1, Aparicio Sánchez JL2.
1Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Departamento de Medicina. Universidad Rey Juan Carlos. Fuenlabrada. Madrid. España.
2Servicio de Pediatría. Neurología Infantil. Hospital Universitario Doctor José Molina Orosa. Arrecife. Las Palmas. España.
Correspondence: M.ª José Rivero Martín. Email: mriverom@salud.madrid.org
Reception date: 04/05/2026
Acceptance date: 12/05/2026
Publication date: 27/05/2026

Abstract

Authors’ conclusions: the optimal doses of intranasal midazolam for procedural sedation in children undergoing laceration repair were 0.4 and 0.5 mg/kg. This finding can inform clinical practice and future studies of intranasal midazolam for procedural sedation.

Reviewers’ comment: overall, the findings support the preferential use of 0.4–0.5 mg/kg for the repair of simple lacerations and may contribute to the standardization of clinical practice. However, their implementation should be approached cautiously in settings with limited technical resources or more heterogeneous populations. The available data do not allow for an adequate assessment of safety regarding rare adverse events.

How to cite this article

Rivero Martín MJ, Aparicio Sánchez JL. Sedación con midazolam intranasal en urgencias pediátricas: ¿cuál es la dosis óptima? Evid Pediatr. 2026;22:17.

AVC | Critically appraised articles

Tsze DS, Woodward HA, McLaren SH, Leu CS, Venn AMR, Hu NY, et al. Optimal dose of intranasal midazolam for procedural sedation in children: a randomized clinical trial. JAMA Pediatr. 2025;179:979-86. 

Reviewers: Rivero Martín MJ1, Aparicio Sánchez JL2.
1Servicio de Pediatría. Hospital Universitario de Fuenlabrada. Departamento de Medicina. Universidad Rey Juan Carlos. Fuenlabrada. Madrid. España.
2Servicio de Pediatría. Neurología Infantil. Hospital Universitario Doctor José Molina Orosa. Arrecife. Las Palmas. España.
Correspondence: M.ª José Rivero Martín. Email: mriverom@salud.madrid.org
Reception date: 04/05/2026
Acceptance date: 12/05/2026
Publication date: 27/05/2026

How to cite this article

Rivero Martín MJ, Aparicio Sánchez JL. Sedación con midazolam intranasal en urgencias pediátricas: ¿cuál es la dosis óptima? Evid Pediatr. 2026;22:17.

27/05/2026

Linked Comment

Methodological note