July 2025. Volume 21. Number 2

HPV vaccine. One dose can be as effective as two doses

 
 
 
 
 
 
 
 
 
 
Rating: 0 (0 Votes)
Newsletter Free Subscription
Regularly recieve most recent articles by e-mail
Subscribe
Print
Add to library
Discuss this article

AVC | Critically appraised articles

Drolet M, Laprise JF, Chamberland E, Sauvageau C, Wilson S, Lim GH, et al. Switching from a 2-dose to a 1-dose program of gender-neutral routine vaccination against human papillomavirus in Canada: a mathematical modelling analysis. CMAJ. 2024;196:e1136-e1143.

Reviewers: Ortega Páez E1, Fraile Astorga G2.
1Pediatra. CS Góngora. Distrito Granada-Metropolitano. Granada. España.
2Pediatra. CS Cuellar. Segovia. España.
Correspondence: Eduardo Ortega Páez. Email: edortegap@gmail.com
Reception date: 08/05/2025
Acceptance date: 19/05/2025
Publication date: 28/05/2025

Abstract

Authors´ conclusions: switching to a one-dose HPV vaccination schedule could maintain population-level health benefits similar to the two-dose schedule while being more efficient in terms of vaccine use.

Reviewers´ commentary: switching from a two-dose to a one-dose schedule in the HPV vaccination program for adolescents may be effective, efficient, and applicable to our setting. However, some uncertainties remain, such as its long-term durability in high-income countries and whether the new regimen could shift HPV infection to adults over 40 years old with unknown consequences. Therefore, more long-term studies would be necessary to confirm the study's findings.

How to cite this article

Ortega Páez E, Fraile Astorga G. Vacuna contra el virus del papiloma humano. Una dosis puede ser tan eficaz como dos dosis. Evid Pediatr. 2025;21:19.

AVC | Critically appraised articles

Drolet M, Laprise JF, Chamberland E, Sauvageau C, Wilson S, Lim GH, et al. Switching from a 2-dose to a 1-dose program of gender-neutral routine vaccination against human papillomavirus in Canada: a mathematical modelling analysis. CMAJ. 2024;196:e1136-e1143.

Reviewers: Ortega Páez E1, Fraile Astorga G2.
1Pediatra. CS Góngora. Distrito Granada-Metropolitano. Granada. España.
2Pediatra. CS Cuellar. Segovia. España.
Correspondence: Eduardo Ortega Páez. Email: edortegap@gmail.com
Reception date: 08/05/2025
Acceptance date: 19/05/2025
Publication date: 28/05/2025

How to cite this article

Ortega Páez E, Fraile Astorga G. Vacuna contra el virus del papiloma humano. Una dosis puede ser tan eficaz como dos dosis. Evid Pediatr. 2025;21:19.

28/05/2025

Linked Comment